Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6- difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non- nucleoside inhibitors of HIV-1 reverse transcriptase

Mai, A., Sbardella, G., Artico, M., Ragno, R., Massa, S., Novellino, E., Greco, G., Lavecchia, A., Musiu, C., La Colla, M., Murgioni, C., La Colla, P., and Loddo, R. . Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6- difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non- nucleoside inhibitors of HIV-1 reverse transcriptase. Journal of Medicinal Chemistry 44, 2544-54. 2001